Anti-PCNA Monoclonal Antibody

英文名称	Anti-PCNA Monoclonal Antibody
别名	Proliferating Cell Nuclear Antigen; DNA polymerase delta auxiliary protein;PCNAR
应用	WB IHC
稀释比例	WB 1:10000-15000. IHC 1:100-300.
交叉反应	Human Mouse Rat
蛋白分子量	29kDa
Gene ID	5111
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG1
免疫原	A synthetic peptide coupled to KLH
性状	液体
Public Immunogen Range	A synthetic peptide coupled to KLH
Subcellular Locations	Nucleus
Swiss Prot	P12004
克隆号	12D10
克隆类型	Monoclonal Antibody
背景资料	PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. It is found in the nucleus and is a cofactor of DNA polymerase delta. PCNA acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6 dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.